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Alzheimer disease

Findings:
No intra- or extra-axial mass lesion or collection is identified. The midline structures are normal with no midline shift.
No sign of atrophy of the midbrain or the cerebellum.
Global cortical atrophy score: 1 – opening of sulci and mild ventricular enlargement.
Koedam score for parietal atrophy: 0 – no atrophy.
Mesial Temporal Atrophy: 3 – marked widening of the choroid fissure, moderate enlargement of the temporal horn, and moderate loss of hippocampal height.
Mild background small vessel ischaemic disease (Fazekas 1).
No loss of the grey-white matter junction is seen.
The visualised paranasal sinuses and mastoid air cells are clear.
No bony abnormality is seen.

Impression:
Moderate mesiotemporal atrophy (MTA score 3) suspicious of Alzheimer disease or limbic-predominant age-related TDP-43 encephalopathy (LATE).

Updated on 30. November 2023

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About the author

Dr Sara Mohebbi is a Consultant Radiologist (Facharzt für Radiologie) with sub-specialty training in neuroradiology. She served as Chief Resident at University Hospital Freiburg and is a member of the European Society of Radiology (ESR). Her clinical focus includes demyelinating disease, neuro-oncology, and vascular neuroimaging. Dr Mohebbi is the Clinical Lead at Radiology Prime, where she provides independent second opinion reports on brain and spine MRI.